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冯磊副教授简介

冯磊,博士,副教授,硕士生导师。2007至2016年就读于大连理工大学,本博直读,获工学博士学位。现工作于dafa黄金版娱乐场体育药物化学教研室,主要从事人体重要代谢酶活性新型检测方法的开发,以及中药活性成分的高通量筛选与药效物质研究。以第一作者发表论文8篇,以通讯作者发表SCI论文7篇,其中影响因子大于10的3篇,大于6的13篇,第一发明人授权专利2项;主持辽宁省自然科学基金面上项目一项,主持精细化工国家重点实验室开放课题2项,参与国家自然科学基金3项;获得辽宁省科技进步奖二等奖一项(第四完成人)。

主要研究方向:

1. 代谢酶活性检测荧光探针的设计、合成及应用

2. 中药活性成分的高通量筛选与药效物质研究

近三年代表性文章:

通讯作者文章:

1.  Molecular design strategy to construct the near-infrared fluorescent probe for selectively sensing human cytochrome P450 2J2, Journal of the American Chemical Society, 2019, 141, 1126−1134.(IF=14.695,ESI高被引)

2.  Targeted enzyme activated two-photon fluorescent probes: a case study of CYP3A4 using a two-dimensional design strategy, Angewandte Chemie International Edition, 2019, 58, 9959−9963 (IF=12.257)

3. Endoplasmic reticulum targeting ratiometric fluorescent probe for carboxylesterase 2 detection in drug-induced acute liver injury, Analytical Chemistry, 2019, 91, 15840−15845. (IF=6.350)

4.   Highly specific near-Infrared fluorescent probe for the real-time detection of β-glucuronidase in various living cells and animals, Analytical Chemistry, 2018, 90, 3276–3283. (IF=6.350)

5.  Activatable near-infrared fluorescent probe for dipeptidyl peptidase IV and its bioimaging applications in living cells and animals, Analytical Chemistry, 2018, 90, 3965–3973. (IF=6.350)

6.  NAG-targeting fluorescence based probe for precision diagnosis of kidney injury, Chemical Communications, 2019, 55, 1955-1958. (IF=6.164)

7.   Heterodimeric diterpenoids isolated from euphorbia ebracteolata roots and their inhibitory effects on α-glucosidase, Journal of Natural Products, 2017, 80, 3218−3223. (IF = 4.257)

8.   Phenolic acids from Balanophora involucrata and their bioactivities, Fitoterapia, 2017, 121, 129–135. (IF = 2.431)

第一作者文章:

1.   Fluorescent probes for bioactive detection and imaging of phase II metabolic enzymes, Coordination Chemistry Reviews, 2019, 399, 213026. (IF=13.467)

2.  Highly selective NIR probe for intestinal β‑glucuronidase and high-throughput screening inhibitors to therapy intestinal damage, ACS Sensors, 2018, 3, 1727−1734.(IF=6.944)

3.   A two-photon ratiometric fluorescent probe for imaging and quantitative analysis of botanic glucosyltransferase: A key enzyme for the biosynthesis of bioactive glycosides, Sensors and Actuators B: Chemical, 2019, 282, 112-121.(IF=6.393)

4.   Identification and isolation of glucosytransferases (GT) expressed fungi using a two-photon ratiometric fluorescent probe activated by GT, Analytical Chemistry, 2018, 90, 13341−13347.(IF=6.350)

5. Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries, Chemical Communications, 2019, 55, 3548-3551 (IF=6.164)

招生专业:

药物化学

联系方式:

leifeng@dmu.edu.cn


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