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孙成鹏副教授简介


孙成鹏,博士,副教授,硕士研究生导师。20166月毕业于沈阳药科大学,获博士学位。任教于dafa黄金版娱乐场体育药物化学教研室,担任天然药物化学课程任课教师。长期从事中药药效物质、抑制剂的开发及神经退行性疾病等方面的研究工作。承担国家自然科学基金项目1省科技厅项目1、大连市科技局项目1项。目前,在PNASJ. Med. Chem.Int. J. Biol. Macromol.Org. Lett.Eur. J. Med. Chem.Food Chem. Toxicol.Phytomedicine等期刊发表SCI科研论文50余篇。担任Front. Chem. (Isolation, Structural Elucidation, and Biological Evaluation of Bioactive Products from Traditional Medicine)编辑,担任Anal. Chim ActaBioorg. Chem.Front. Pharmacol.J. Agr. Food Chem.等期刊特约审稿人。荣获辽宁省科技进步二等奖和大连市青年科技之星,任世界中联中药化学专业委员会理事、中国仪器仪表学会药物质量分析与过程控制分会理事大连市药学会天然药物专业委员会委员。

 

主要研究方向:

1中药药效物质

2可溶性环氧化物水解酶(sEH)抑制剂的发现及其在神经退行性疾病中的应用

3肠道微生物的次生代谢产物研究

联系方式:suncp146@163.com

近年发表的科研论文:

1. Sun CP, Zhou JJ, Yu ZL, Huo XK, Zhang J, Morisseau C, Hammock BD, Ma XC. Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model. Proc Natl Acad Sci U S A 2022, 119, e2118818119. (第一作者,IF=11.205)

2. Sun CP, Zhang XY, Morisseau C, Hwang SH, Zhang ZJ, Hammock BD, Ma XC. Discovery of soluble epoxide hydrolase inhibitors from chemical synthesis and natural products. J Med Chem 2021, 64, 184-215. (第一作者,IF=7.446)

3. Lv X, Bai R, Yan JK, Huang HL, Huo XK, Tian XG, Zhao XY, Zhang BJ, Zhao WY, Sun CP. Investigation of the inhibitory effect of protostanes on human carboxylesterase 2 and their interaction: Inhibition kinetics and molecular stimulations. Int J Biol Macromol 2021, 167, 1262-1272. (通讯作者,IF=6.953)

4. Sun CP, Yan JK, Yi J, Zhang XY, Yu ZL, Huo XK, Liang JH, Ning J, Feng L, Wang C, Zhang BJ, Tian XG, Zhang L, Ma X. The study of inhibitory effect of natural flavonoids toward beta-glucuronidase and interaction of flavonoids with beta-glucuronidase. Int J Biol Macromol 2020, 143, 349-358. (第一作者,IF=6.953)

5. He X, Zhao WY, Shao B, Zhang BJ, Liu TT, Sun CP, Huang HL, Wu JR, Liang JH, Ma XC. Natural soluble epoxide hydrolase inhibitors from Inula helenium and their interactions with soluble epoxide hydrolase. Int J Biol Macromol 2020, 158, 1362–1368. (通讯作者,IF=6.953)

6. Zhang J, Zhao WY, Wang C, Yi J, Yu ZL, Deng S, Zhang HL, Huo XK, Sun CP, Ma XC. Identification, semisynthesis, and anti-inflammatory evaluation of 2,3-seco-clavine-type ergot alkaloids from human intestinal fungus Aspergillus fumigatus CY018. Eur J Med Chem 2021, 224, 113731. (通讯作者,IF=6.514)

7. Luan ZL, Huo XK, Dong PP, Tian XG, Sun CP, Lv X, Feng L, Ning J, Wang C, Zhang BJ, Ma XC. Highly potent non-steroidal FXR agonists protostane-type triterpenoids: Structure-activity relationship and mechanism. Eur J Med Chem 2019, 182, 111652. (通讯作者,IF=6.514)

8. Wang C, Huo XK, Luan ZL, Cao F, Tian XG, Zhao XY, Sun CP, Feng L, Ning J, Zhang BJ, Ma XC. Alismanin A, a Triterpenoid with a C34 Skeleton from Alisma orientale as a Natural Agonist of Human Pregnane X Receptor. Org Lett 2017, 19, 5645-5648. (通讯作者,IF=6.492)

9. Sun CP, Zhang XY, Zhou JJ, Huo XK, Yu ZL, Morisseau C, Hammock BD, Ma XC. Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer's disease through GSK3beta signaling pathway. Food Chem Toxicol 2021, 156, 112516. (第一作者,IF=6.023)

10. Luan ZL, Qiao F, Zhao WY, Ming WH, Yu ZL, Liu J, Dai SY, Jiang SH, Lian CJ, Sun CP, Zhang BJ, Zheng J, Ma SC, Ma XC. Discovery of new iridoids as farnesoid X receptor agonists from Morinda officinalis: Agonistic potentials and molecular stimulation. Chinese J Chem 2021, 39, 1288-1296. (通讯作者,IF=6.00)

 

 

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