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孟强教授简介

孟强,1980年5月生,教授,任教于dafa黄金版娱乐场体育临床药理教研室,是辽宁省药代动力学与药物转运重点实验、辽宁省抗肝炎创新药物工程技术研究中心成员,兼任中国药理学会药物代谢专业委员会青年委员会副主任委员及大连市药学会药理专业委员会委员。长期从事肝脏疾病治疗药物的分子机制、药代动力学和药物转运体研究,有丰富的分子药理学、药动学的理论和实践研究经验,在转运体介导的各种急慢性肝损伤病理机制及药物治疗分子机制的探索方面具有丰富的经验。2014年至今已在国际一流杂志Biochem Pharmacol(2014, 92, 289-298,影响因子5.009),Toxicol Appl Pharmacol(2015, 283, 178-186,影响因子3.847),Pharm Res(2015, 32, 3688-3698影响因子3.26)等发表SCI论文50余篇。主持及参与国家自然科学基金、省教育厅等多项基金,获辽宁省自然科学学术成果2等奖及大连市自然科学优秀学术论文2等奖各两项,辽宁省科技进步2等奖及大连市科技进步1等奖各一项。参编《药理学》、《临床药理学》、《临床药物代谢动力学》等多部教材。

研究方向:
1. 肝脏疾病治疗药物的分子药理学机制研究
2. 转运体和代谢酶介导的肝病分子机制研究

主持项目:
1. 国家自然科学基金,泽泻醇B 23-乙酸酯促肝再生作用的分子机制和作用靶点,2014/01-2016/12
2. 辽宁省重点实验室项目,转运体和酶介导的泽泻醇B 23-乙酸酯抗LCA所致胆汁淤积性肝损伤的分子药代动力学机制,2015/01-2018/12

代表性论文:
1. Qiang Meng(第一作者), Xinli Chen, Changyuan Wang, Qi Liu, Huijun Sun, Pengyuan Sun, Jinyong Peng, Kexin Liu. Alisol B 23-acetate promotes liver regeneration in mice after partial hepatectomy via activating farnesoid X receptor. Biochemical Pharmacology, 92(2): 289-298, 2014  IF: 5.009
2. Gao X, Fu T, Wang C, Ning C, Kong Y, Liu Z, Sun H, Ma X, Liu K, Meng Q(通讯作者). Computational discovery and experimental verification of farnesoid X receptor agonist auraptene to protect against cholestatic liver injury. Biochem Pharmacol. 2017, 146: 127-138.   IF: 4.235
3. Kong Y, Gao X, Wang C, Ning C, Liu K, Liu Z, Sun H, Ma X, Sun P, Meng Q(通讯作者). Protective effects of yangonin from an edible botanical Kava against lithocholic acid-induced cholestasis and hepatotoxicity. Eur J Pharmacol. 2018 Apr 5; 824: 64-71 . IF: 3.04
4. Gao X, Fu T, Wang C, Ning C, Liu K, Liu Z, Sun H, Ma X, Huo X, Yang X, Zou M, Meng Q(通讯作者). Yangonin protects against cholestasis and hepatotoxity via activation of farnesoid X receptor in vivo and in vitro. Toxicol Appl Pharmacol. 2018 Jun 1;348:105-116.  IF: 3.616
5. Gao X, Wang C, Ning C, Liu K, Wang X, Liu Z, Sun H, Ma X, Sun P, Meng Q(通讯作者). Hepatoprotection of auraptene from peels of citrus fruits against thioacetamide-induced hepatic fibrosis in mice by activating farnesoid X receptor. Food Funct. 2018 May 23;9(5):2684-2694.  IF: 3.289
6. Duan X, Meng Q(共同通讯), Wang C, Liu Z, Sun H, Huo X, Sun P, Ma X, Peng J, Liu K.Effects of calycosin against high fat diet-induced nonalcoholic fatty liver disease in mice. J Gastroenterol Hepatol. 2018 Feb;33(2):533-542.  IF: 3.483
7. Xue Sun, Xingping Duan, Changyuan Wang, Zhihao Liu, Pengyuan Sun, Xiaokui Huo, Xiaodong Ma, Huijun Sun, Kexin Liu, Qiang Meng(通讯作者). Protective effects of glycyrrhizic acid against non-alcoholic fatty liver disease in mice. Eur J Pharmacol, 2017, 806:75-82  IF: 3.04
8. Duan X, Meng Q(共同通讯), Wang C, Liu Z, Liu Q, Sun H, Sun P, Yang X, Huo X, Peng J, Liu K. Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor. Phytomedicine. 2017 Feb 15;25:83-92. IF: 3.526
9. Qiang Meng(第一作者), Kexin Liu. Pharmacokinetic Interactions Between Herbal Medicines and Prescribed Drugs: Focus on Drug Metabolic Enzymes and Transporters. Current Drug Metabolism, review, 15(8): 791-807, 2014  IF: 2.976
10. Qiang Meng(第一作者), Xin-li Chen, Chang-yuan Wang, Qi Liu, Hui-jun Sun, Peng-yuan Sun, Xiao-kui Huo, Zhi-hao Liu,Ji-hong Yao, Ke-xin Liu. Alisol B 23-acetate protects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes involved in bile acid homeostasis. Toxicology and Applied Pharmacology, 283(3): 178-186, 2015  IF: 3.847
11. Qiang Meng(第一作者), Xinli Chen, Changyuan Wang, Qi Liu, Huijun Sun, Pengyuan Sun, Xiaokui Huo, Zhihao Liu and Kexin Liu. Protective effects of alisol B 23-acetate from edible botanical Rhizoma alismatis against carbon tetrachloride-induced hepatotoxicity in mice. Food Funct, 6(4): 1241-1250, 2015  IF: 2.686
12. Qiang Meng(第一作者), Xinli Chen, Changyuan Wang, Qi Liu, Huijun Sun, Pengyuan Sun, Xiaokui Huo, Zhihao Liu, Jihong Yao, Kexin Liu. Protective Effects of Alisol B 23-Acetate Via Farnesoid X Receptor-Mediated Regulation of Transporters and Enzymes in Estrogen-Induced Cholestatic Liver Injury in Mice. Pharm Res, 32(11): 3688–3698, 2015  IF: 3.26
13. Changyuan Wang, Xingping Duan, Xue Sun, Zhihao Liu, Pengyuan Sun, Xiaobo Yang, Huijun Sun, Kexin Liu, Qiang Meng(共同通讯). Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice. Food Funct, 7(9): 3716-3723, 2016  IF: 2.686
14. Qiang Meng(第一作者,共同通讯), Xingping Duan, Changyuan Wang, Zhihao Liu, Pengyuan Sun, Xiaokui Huo, Huijun Sun, Jinyong Peng, Kexin Liu. Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation. Acta Pharmacol Sin, 38(1): 69-79, 2017  IF: 3.166
15. 孟强(第一作者),刘克辛。核受体FXR在肝再生中的作用。世界华人消化杂志, 综述,21(34): 3767-3774, 2013

获奖:
1. 辽宁省自然科学学术成果二等奖(学术论文类),2015年,证书号:163104700022300
获奖题目:Alisol B 23-acetate protects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes involved in bile acids homeostasis
2. 辽宁省自然科学学术成果二等奖(学术论文类),2015年,证书号:2015-LNL0011
   获奖题目:Alisol B 23-acetate promotes liver regeneration in mice after partial hepatectomy via activating farnesoid X receptor
3. 大连市自然科学优秀学术论文二等奖,2016年,证书号:2016-079
获奖题目:泽泻醇B 23-乙酸酯通过调控法尼醇X受体介导的胆汁酸转运体和代谢酶对胆汁淤积性肝损伤的保护作用
4. 大连市自然科学优秀学术论文二等奖,2015年,证书号:2015-110
获奖题目:泽泻醇B 23-乙酸酯通过激活法尼醇X受体促进小鼠部分肝切除后的肝再生作用

联系方式:
mengq531@163.com

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