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浏览文章 【2019-04-12 15:52:11】  【点击数:】【字号: 】 【我要打印

王超教授简介

王超,博士,教授,硕士生导师,无党派人士。2013年6月毕业于中国医学科学院&北京协和医学院药物研究所,获得理学博士学位。现于dafa黄金版娱乐场体育药物化学教研室担任天然药物化学课程任课教师。主要从事中药药效物质的分离、生物活性及作用机制、代谢属性等方面的研究工作。承担国家自然科学基金项目2项、省教育厅项目1项等。发表SCI科研论文40余篇,获得4项省部级科技奖励。入选辽宁省“百千万人才工程”,荣获大连市青年科技之星称号,任大连市药学会天然药物专业委员会委员。


主要研究方向:
(1)传统中药药效物质的分离、鉴定及生物活性研究
(2)中药成分对肠道菌及其关键功能酶的影响
(3)中药药效物质的代谢属性研究
(4)小分子荧光探针用于微生物功能酶的检测及活性天然产物的发现
(5)多途径(生物酶、微生物、化学合成)介导的活性天然产物的结构修饰
近年发表的科研论文:
1) C. Wang, X. Huo, Z. Luan, F. Cao, X. Tian, X. Zhao, C. Sun*, L. Feng, J. Ning, B. Zhang, X. Ma*. Alismanin A, a Triterpenoid with a C34 Skeleton from Alisma orientale as a Natural Agonist of Human Pregnane X Receptor. Org. Lett. 2017, 19, 5645−5648.
2) T. Liu, Q.L. Yan, L. Feng, X.C. Ma, X.G. Tian, Z.L. Yu, J. Ning, X.K. Huo, C.P. Sun, C. Wang*, J.N. Cui*. Isolation of γ-Glutamyl-Transferase Rich-Bacteria from Mouse Gut by a Near-Infrared Fluorescent Probe with Large Stokes Shift. Anal. Chem., 2018, 90, 9921−9928.
3) X.X. Gao, C.P. Sun, Z.L. Yu, J. Cang, X.G. Tian, X.K. Huo, L. Feng, X.G. Liu, C. Wang*, B.J. Zhang, X.C. Ma*. Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma. Acta Pharm. Sin. B 2018, 8, 242–251.
4) L. Feng, Y.L. Yang, X.K. Huo, X.G. Tian, Y.J Feng, H.W Yuan, L.J. Zhao, C. Wang*, P. Chu, F.D. Long, W. Wang*, X.C. Ma*. Highly selective NIR probe for intestinal β-Glucuronidase and Highthroughput screening inhibitors to therapy intestinal damage. ACS Sensors, 2018, DOI: 10.1021/acssensors.8b00471.
5) X. Gao, S. Huang, P. Dong, C. Wang,* J. Hou,  X. Huo, B. Zhang, T. Ma, X, Ma*. Horseradish peroxidase (HRP): a tool for catalyzing the formation of novel bicoumarins. Catal. Sci. Technol., 2016, 6(10): 3585-3593.
6) C. Wang, X.K. Huo, X.G. Tian, M. Xu, P.P. Dong, Z. Luan, X. Wang, B. Zhang, B. Zhang, S. Huang, S. Deng, X. Ma. Inhibition of melatonin metabolism in humans induced by chemical components from herbs and effective prediction of this risk using a computational model. Br. J. Pharmacol., 2016, 173 3261–3275.
7) M. Xu, P. Dong, X. Tian, C. Wang*, X.K. Huo, B.J. Zhang, L. Wu, S. Deng, X.C. Ma*. Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyl transferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for prediction. Pharmacol. Res., 2016, 110, 139–150.
8) Y. Cui, X. Tian, J. Ning, C. Wang,* Z. Yu, Y. Wang, X. Huo, L. Jin, S. Deng, B. Zhang, X. Ma*. Metabolic profile of 3-acetyl-11-keto-β-boswellic acid and 11-keto-β-boswellic acid in human preparations in vitro, species differences, and bioactivity variation. The AAPS Journal, 2016, 18, 1273–1288.
9) C. Wang, Q. Yan, Y. Ma, C. Sun, C. Chen, X. Tian, X. Han, C. Wang,* S. Deng, Xiao-Chi Ma*. ent-Abietane and tigliane diterpenoids from the roots of Euphorbia fischeriana and their inhibitory effects against Mycobacterium smegmatis. J. Nat. Prod., 2017, 80(5): 1248-1254.
10) X.R. Zhao, X.K. Huo, P.P. Dong, C. Wang,* S.S. Huang, B.J. Zhang, H.L. Zhang, S. Deng, K.X. Liu, Xiao-Chi Ma*. Inhibitory effects of highly oxygenated lanostane derivatives from the Fungus Ganoderma lucidum on P-glycoprotein and α-glucosidase. J. Nat. Prod., 2015, 78, 1868−1876.
11) Z. Mai, K. Zhou G. Ge, C. Wang,* X. Huo, P. Dong, S. Deng, B. Zhang, H. Zhang, S. Huang, X. Ma*. Protostane triterpenoids from the rhizome of Alisma orientale exhibit inhibitory effects on human carboxylesterase 2. J. Nat. Prod., 2015, 78, 2372−2380.
12) C. Wang, C. Li, J. Yang, J. Ma, X. Chen, Q. Hou, D. Zhang*. Anti-inflammatory sesquiterpene derivatives from the leaves of Tripterygium wilfordii. Journal of Natural Products, 2013, 76, 85–90.
13) A.H. Wang, X.G. Tian, Y.L. Cui, X.K. Huo, B.J. Zhang, S. Deng, L. Feng, X.C. Ma, J.M. Jia*, C. Wang*. Diterpenoids from the roots of Euphorbia ebracteolata and their inhibitory effects on human carboxylesterase 2. Phytochemistry, 2018, 146, 82–90.
14) B Wang, Y.L. Wei, X.Y. Zhao, X.G. Tian, J. Ning, B.J. Zhang, S. Deng, D.W. Li*, X.C. Ma*, C. Wang*. Unusual ent-atisane type diterpenoids with 2-oxopropyl skeleton from the roots of Euphorbia ebracteolata and their antiviral activity against human rhinovirus 3 and enterovirus 71. Bioorg. Chem., 2018, 81, 234–240.
15) Zhenlong Yu, Yunlong Wei, Xiangge Tian, Qiulong Yan, Qingsong Yan, Xiaokui Huo, Chao Wang*, Chengpeng Sun, Baojing Zhang, Xiaochi Ma*. Diterpenoids from the roots of Euphorbia ebracteolata and their anti-tuberculosis effects. Bioorg. Chem., 2018, 77, 471–477.
16) Chunhui Han, Yulin Peng, Yifei Wang, Xiaokui Huo, Baojing Zhang, Dawei Li*, Aijing Leng, Houli Zhang, Xiaochi Ma*, Chao Wang*. Cytotoxic ent-Abietane-type diterpenoids from the roots of Euphorbia ebracteolata. Bioorg. Chem., 2018, 81, 93–97.
17) P. Li, C. Suna, Y. Wang, S. Wang, C. Yan, S. Deng, X. Huo, L. Feng, C. Wang,* Y. Tian, B. Zhang, X. Ma*. Efficiently regioselective glucosylation of estrogen analogues mediated by fungus Rhizopus oryzae AS 3.2380. Catal. Commun., 2017, 97, 106–110.
18)  C. Wang, X. Huo, B. Zhang, C. Sun, X. Tian, S. Deng, B. Li, W. Wang. Dong, X. Ma. Highly regioselective glucosylation of alcoholic hydroxyls of protostane triterpenoids mediated by fungal biotransformation. Catal. Commun., 2017, 89, 40–43. 
19) M. Xu, X. Huo, X. Tian, P. Dong, C. Wang,* S. Huang, B. Zhang, H. Zhang, S. Deng, X. Ma*. Microbial transformation of diosgenin by Cunninghamella blakesleana AS 3.970 and potential inhibitory effects on P-glycoprotein of its metabolites. RSC Adv., 2015, 5, 78081-78089. 
20) C. Wang, P. Dong, L. Zhang, X. Huo, B. Zhang, C. Wang, S. Huang, X. Wang,* J. Yao, K. Liu, X. Ma. Regio- and stereo- selective oxidation of β-boswellic acids transformed by filamentous fungi. RSC Adv., 2015, 5, 12717–12725.

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